Eplerenone API
A remarkably selective mineralocorticoid receptor antagonist primarily anchoring high-grade antihypertensive systems and cardiovascular risk reduction segments.
CAS Number
107724-20-9
Formula
C₂₄H₃₀O₆
Mol. Weight
414.49 g/mol
Grade
USP / EP / BP / IP
Product Overview
Eplerenone operates clinically as a highly selective mineralocorticoid receptor antagonist specifically engineered to forcefully block the pathological action of aldosterone. As a highly active agent within the rapidly expanding antihypertensive and complex cardiovascular risk-modification segment, it remains an unquestionable powerhouse specifically targeting hypertension factors alongside deep heart failure indications—frequently synthesized into powerful multi-vector combination therapies.
As a global commercial distributor, Jay Overseas explicitly sources Eplerenone API directly from intensely qualified suppliers operating under impenetrable quality management frameworks. This profoundly ensures massive batch-to-batch consistency and airtight material traceability perfectly poised for extensive long-term commercial formulation programs and complex international dossier submissions.
Cardiovascular Positioning
Targets crucial metabolic markers lowering systemic blood pressure violently safely.
Dossier Development
Supports comprehensive technical packages ready for instant regulatory submission.
API Snapshot
Receptor Mechanism Dynamics
Aldosterone Secretion
The targeted biological system excessively produces aldosterone, inherently driving dangerously severe cardiovascular inflammation and systemic hypertension.
Receptor Blockade
Eplerenone uniquely operates as a wildly selective antagonist forcibly blocking active aldosterone from reaching sensitive mineralocorticoid receptors purely.
Risk Reduction
This blockade drastically prevents severe subsequent molecular pathway damage, radically lowering cardiovascular pressure while stabilizing massive failure events.
Therapeutic Applications
Antihypertensive Therapies
Highly targeted formulation bases engineered specifically for advanced, aggressive systemic blood pressure control.
Cardiovascular Risk Reduction
Deployed extensively inside complex risk-modifying pipelines directly reducing severe heart failure incident rates.
Combination Vector Scaling
Powerfully integrated directly alongside secondary cardiovascular agents aligning strongly with modern multi-pathway market requirements.
Aldosterone Inhibition
Strictly targets and explicitly neutralizes aldosterone receptors stopping heavily destructive downstream metabolic swelling.
Clinical Advantages & Value Proposition
Provides exceptionally profound chemical stability allowing for deeply diverse, highly adaptable formulation scaling universally across cardiovascular applications.
Functions distinctly as a highly selective mineralocorticoid receptor antagonist blocking dangerous aldosterone binding
Presents structurally as a profoundly stable, white to off-white crystalline solid mapping flawlessly to solid oral scaling
Guaranteed continuous technical compliance flawlessly aligned directly to major USP, EP, BP, and IP testing frameworks
Offers comprehensive traceability and deep longitudinal availability ensuring highly resilient long-term commercial supply lines
Technical Specifications Table
Supported fully under heavy CEP/DMF Documentation (USP/EP/BP Formats)*
| Sr. | Diagnostic Parameter | Regulatory Bounds Limit |
|---|---|---|
| 1 | Description | White to off-white crystalline powder |
| 2 | Identification | IR spectrum conforms to Eplerenone reference standard |
| 3 | Solubility | Very slightly soluble in water; soluble in organic solvents (DMSO) |
| 4 | Melting Range | Approx. 241 – 243 °C |
| 5 | Water Content (Karl Fischer) | Not more than 1.0 %* |
| 6 | Related Substances (HPLC) | Any individual: NMT 0.2 %* | Total impurities: NMT 1.0 %* |
| 7 | Sulphated Ash | NMT 0.1 %* |
| 8 | Heavy Metals | NMT 20 ppm* |
| 9 | Residual Solvents | Complies with ICH Q3C guidelines |
| 10 | Assay (Anhydrous Basis) | 98.0 % – 102.0 %* |
* Exact analytical limits and testing values rigidly depend upon specific manufacturer origins and are explicitly provided via isolated commercial COA profiling parameters dynamically.
Why Sourcing with Jay Overseas Is Essential
We ensure flawless quality execution driving powerful batch-to-batch API consistency endlessly.
Regulatory Excellence
Engineered within WHO-GMP compliant facilities natively boasting rigorous pharmacopeial alignment and active DMF/CEP-linked documentation integration.
Controlled Purity Metrics
Reliably odorless, heavily controlled crystalline framework demonstrating ultra-low impurity metrics thoroughly validated against major global pharmacopeias.
Global Supply Networks
Fully export-ready clearance mapping, natively supporting highly flexible batch scale structuring to accurately feed globally regulated pharmaceutical ecosystems.
Export Level Packaging
Rigidly secured utilizing double LDPE internal bags comprehensively insulated within dense HDPE or Fiber drum systems natively spanning 5kg to 25kg metrics.
Baseline Environment
Store rigorously guarded directly at room temperature keeping profoundly sealed within completely cool, absolutely dry parameters avoiding hostile light exposures.
Long-Term Extension
When rigidly stored complying to strict environmental factors, natively guarantees absolutely massive operational stability lifespans universally pushing 36 to 48 months extensively.
Initiate API Distribution Logistics
Connect swiftly with our technical integration teams to secure immediate Eplerenone samples, precise quotations, and comprehensive regulatory clearance documentation worldwide.
Legal Disclaimer: Eplerenone strictly functions explicitly as an active clinical raw component. Disbursed and traded entirely strictly to profoundly registered, highly licensed pharmaceutical compilation structures actively globally. The explicit raw API unconditionally remains completely prohibited from informal commercial utilization organically directly.