Picosulfate Sodium
A precisely controlled, prodrug-based stimulant laxative heavily utilized worldwide for highly predictable pre-procedural bowel evacuation dynamics.
CAS Number
10040-45-6
Formula
C₁₈H₁₃NNa₂O₈S₂
Mol. Weight
481.41 g/mol
Grade
BP / EP / USP
Product Overview
Picosulfate Sodium formally operates as a highly specific prodrug compound. It requires explicit hydrolysis by colonic bacteria to break down into its active metabolite, bis-(p-hydroxyphenyl)-pyridyl-2-methane (BHPM). This profoundly localized biological mechanism explicitly stimulates the colonic mucosa to heavily increase peristaltic contractions.
As a global commercial trading leader, Jay Overseas strictly emphasizes sourcing this highly essential API directly from certified facilities maintaining complex regulatory profiles. It functions globally as the unquestionable foundation for chronic constipation therapeutics and exhaustive pre-colonoscopy bowel cleansing regimens globally.
Local Intestinal Activation
Targets the exact required motility structures bypassing major blood barriers safely.
Predictable Action Profiling
Strict pharmacological control specifically tailored for exact pre-procedural timelines.
API Snapshot
Colonic Mechanism of Action
Prodrug Administration
Delivered cleanly as a triphenylmethane derivative, the chemical safely passes the upper gastrointestinal structures with zero premature breakdown.
Bacterial Hydrolysis
Upon entering the colon, the inactive API vigorously undergoes explicit bacterial hydrolysis entirely driven by resident lower colonic microbiota.
Motility Secretion
The resulting active BHPM metabolite forcefully binds to the enteric nervous system, prompting highly elevated intestinal motility and critical bowel evacuation.
Therapeutic Applications
Diagnostic Bowel Prep
Highly aggressive, clean bowel preparation standardly utilized preceding colonoscopies.
Colorectal Surgical Prep
Strict pre-operative bowel evacuation safely executed directly prior to complex colorectal surgical events.
Radiological Diagnostics
Supports highly sensitive radiological examinations heavily demanding an absolutely clean bowel matrix.
Chronic Constipation
Measured, long-term pharmacological treatment pathways for recurring chronic constipation profiles.
Clinical Advantages & Value Proposition
Its highly explicit mechanism isolates systemic breakdown risks, making it uniquely reliable for exceptionally vulnerable diagnostic preparation protocols.
Predictable, fully manageable onset of action naturally triggering within 6-12 hours
Radically minimal systemic absorption due to its localized activation in the lower colon
Fails to induce harmful electrolyte imbalances when rigidly kept at established therapeutic dosing ranges
Highly adaptable physical framework capable of formulation into standard tablets, solutions, or pediatric drops
Detailed BP Grade Specifications
DMF Verification Available | Full Global Regulatory Support
| Sr. | Criteria Phase | Global Specification Limits |
|---|---|---|
| 1 | Description | White to slightly pink crystalline powder |
| 2 | Solubility | Freely soluble in water, sparingly soluble in alcohol |
| 3 | Identification | IR spectrum conforms to reference standard (BP) |
| 4 | pH (1% solution) | 8.5 – 10.0 |
| 5 | Loss on Drying | Not more than 10.0% |
| 6 | Related Substances (HPLC) | BHPM: NMT 0.5% | Total impurities: NMT 1.5% |
| 7 | Sulfated Ash | 20.0% – 24.0% |
| 8 | Heavy Metals | NMT 20 ppm |
| 9 | Assay (Dried, HPLC) | 98.0% – 102.0% |
| 10 | Microbial Limits | Aerobic: NMT 1000 CFU/g | E.coli/Salmonella: Absent |
Why Partner with Jay Overseas
Ensuring your supply chains function under flawlessly audited compliance parameters globally.
Global Supply Networks
Consistent global availability backed tightly by efficient international logistics to 45+ countries through our extensive pharmaceutical trading nexus.
Pharmaceutical Grade Purity
Consistent high-purity API production featuring uncompromisingly stringent impurity control limits backed by deeply transparent analytical batch documentation.
Uncompromising Compliance
API exclusively sourced from USFDA DMF filed and WHO-GMP certified facilities maintaining formal compliance tightly to major BP, EP, and USP standards.
Export Level Packaging
Double LDPE internal barriers protected inherently by robust HDPE or thick fiber drum encasements. Export-worthy customs labeling fully administered.
Storage Execution
Must rigidly store in environments natively below 25°C (77°F). Extensively protect all exposures precisely from sudden light and latent local moisture elements.
Commercial Shelf Life
Guarantees formal 36-month stability thresholds mapped rigorously according precisely to formal ICH Q3C baseline validation guidelines.
Construct Your Dosage Portfolio
Reach out to our expert commercial teams today for dispatch of testing batches, customizable packaging protocols, and immediate provision of our expansive DMF documentation.
Legal Disclaimer: Picosulfate Sodium API rigorously functions as an active biological raw material. It is exclusively engineered strictly for professional manufacturing compilation entities only. Usage falls entirely within highly specific clinical importation compliances. Formulations explicitly remain strictly non-consumable directly.