5-Chloro-4-Amino-2,1,3
Benzothiadiazole
A fundamentally versatile heterocyclic precursor deeply embedded inside aggressive multi-step synthesis for dominant Cardiovascular and CNS pharmaceutical formulations.
CAS Number
29270-56-2
Formula
C₆H₄ClN₃S
Mol. Weight
185.63 g/mol
Min. Purity
≥ 98.0%
Precursor Overview
5-Chloro-4-Amino-2,1,3-Benzothiadiazole is fundamentally revered as an intensely critical heterocyclic organic compound structurally loaded with severe chloro and amino substituents. This precise structural combination acts exclusively as a massively versatile foundation deliberately enabling heavily complex chemical transformations spanning dozens of critical API classifications entirely.
Distributed with unparalleled absolute traceability, Jay Overseas structurally executes highly advanced mult-step engineering processes—predominantly spanning precise chlorination and amination reactions heavily—generating incredibly stable extraction outputs. Every batch operates universally supported by deep ¹H and ¹³C NMR validation matrices perfectly ensuring rapid global compliance scaling.
Heavy Vertical Scaling
Ensuring an extraordinarily reliable raw material integration bridge explicitly.
Impurity Neutralization
Holds rigorous single impurity markers stringently below NMT 0.5% absolutely.
Specification Snapshot
Precision Synthesis Control
Sequential Chlorination
Begins via profoundly controlled early-stage halogenation routing inserting exact structural chloro boundaries securing immense stability baselines perfectly.
Amination Integration
Operates highly refined amination substitutions actively yielding the required reactive properties inherently needed to support massive heterocyclic formulation scaling.
Spectral Validation
Immediately subjected violently across absolute FTIR/NMR matrices forcing heavy structural verification parameters strictly confirming flawless isomeric arrangements.
Applications in API Synthesis
Cardiovascular API Generation
Acts purely as a structural foundation actively integrated inside complex multi-stage cardiovascular molecule formulations.
CNS Pipeline Synthetics
Provides immense heterocyclic stability serving directly as the dominant building block driving CNS-active pharmaceutical compounds.
Precursor Transformations
Possesses a heavily versatile core enabling dramatically diverse chemical transformations bridging disparate therapeutic agents natively.
R&D Architecture Integration
A profound chemical mechanism supporting sweeping clinical pilot runs massively expanding cutting-edge research environments.
Structural Yield & Analytical Sovereignty
Functions entirely backed by immense state-of-the-art analytical equipment actively mapping exact complex characterizations flawlessly securing total bulk formulation operations deeply.
Maintains extraordinarily high chemical baseline stability and absolute batch-to-batch execution immutability at massive industrial scale
Engineered using a multi-step optimized purification process yielding incredibly dense active thresholds matching ≥98.0% cleanly
Routinely validated utilizing the most exhaustive heavy analytics encompassing precise HPLC, Mass Spectrometry, and ¹³C NMR baselines
Fully enabled by profound documentation ecosystems granting immediate access to advanced Spectral Data and Safety Data Sheets (SDS)
Chemical Specifications Matrix
Robust Pharmaceutical Grade Intermediate Parameters
| Sr. | Diagnostic Parameter | Target Specification Limit |
|---|---|---|
| 1 | Description | Yellow to orange-brown crystalline powder |
| 2 | Solubility | Soluble tightly in DMF, DMSO; sparingly soluble in ethanol extracts |
| 3 | Identification (FTIR) | IR spectrum matches universally with reference standard |
| 4 | Identification (NMR) | Both ¹H NMR and ¹³C NMR perfectly confirm complex core structure |
| 5 | Melting Point Execution | 170°C – 175°C |
| 6 | Loss on Drying | Not more than 0.5% |
| 7 | Residue on Ignition | Not more than 0.1% |
| 8 | Related Substances (HPLC) | Any single impurity: NMT 0.5% | Total overall impurities: NMT 2.0% |
| 9 | Heavy Metals / Chloride | Metals: NMT 20 ppm | Chloride Content: 18.5% – 19.5% (Theoretical: 19.1%) |
| 10 | Residual Solvents | Strictly complies with massive ICH Q3C parameters |
| 11 | Base Assay (Validated HPLC) | 98.0% – 102.0% yielding immense scale efficiency |
Why Sourcing with Jay Overseas Fortifies Security
We actively govern incredibly strict logistical containment bridging complex supply chains natively.
Vertical Synthesizer Supply
A completely integrated international manufacturing baseline structurally feeding deeply regulated commercial synthesis endpoints globally.
Massive GMP Execution
All synthesis routing operations take place effectively underneath heavily validated state-of-the-art GMP manufacturing facilities securely.
Traceable Immutability
Supported actively by exhaustive impurity profiling, spectral data verification (NMR/MS), and complete longitudinal batch tracking.
Raw Material Aggregation
Utilizes actively rigid double LDPE internal architecture embedded strictly inside highly protective 10kg, 25kg, and large 50kg bulk HDPE scaling drum variants.
Ambient Structural Defense
Operates perfectly strictly under dedicated room temperature matrices spanning 15°C – 30°C massively forcing away external corrosive atmospheric parameters constantly.
Valid Core Integrity Limit
Produces rigorously enforced stable execution lines actively retaining total functional stability flawlessly holding completely massive 24 month commercial shelf spans.
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